91大神

Position Description

Every great life-changing discovery begins the same way鈥攚ith new knowledge. It can change everything, from a single life to the future of entire communities. That鈥檚 why academic medicine, and the continuous pursuit of knowledge, is at the center of everything we do at the 91大神 College of Wisconsin (MCW).

Purpose

In the role of Department Administrator in Biophysics, reporting to the Department Chair, you will direct the administrative and financial activities of a basic science department to include all financial, human and physical resources needed to carry out departmental goals effectively and efficiently. Function as the department鈥檚 agent and representative with internal and external entities.

Primary Functions

• Responsible for the smooth function and development of department administrative operations to include information systems, contract development and negotiations, as well as, system design and development to support all department functions.
• Develop annual budget. Monitor expenditures in relation to established budget, develop budget controls and reports, and analyze data against benchmarks.
• In conjunction with Department Chair, develop and monitor strategic long- and short-term program and space planning including building design. Set priorities and goals.
• Develop and monitor administrative infrastructure to support department operations to include staffing levels, compensation plan, organizational development, recruitment and retention, and team building.
• Integrate and coordinate department activities with 91大神administration, internal and external entities. Negotiate contracts as required.
• Develop and monitor systems for auditing and tracking financial matters. Monitors department compliance of operational policies and procedures. Work with department faculty regarding grant writing, adherence to budget guidelines, and opportunities for extramural funding.
• In conjunction with Department Chair, develop and assess internal and external partnership opportunities.
• Serve as advisor to chair on non-research issues including strategic planning, faculty hiring and disciplinary practices, faculty salary and institutional and inter-institutional negotiations.

Knowledge 鈥� Skills 鈥� Abilities

• Possess excellent oral and written communication skills.
• Set and communicate priorities, effectively planning and organizing the work of the group.
• Possess strong critical thinking, problem solving and attentiveness to detail.
• Apply education, training, and work experience to improve the performance of the organization.
• Lead by setting an appropriate example.
• Successfully manage stressful situations and change effectively.
• Foster teamwork.
• Clearly communicate information necessary for business success.
• Delegates work effectively.
• Maintain confidences.
• Demonstrate personal integrity in all interactions.

Position. The 91大神 College of Wisconsin (MCW) Cancer Center (CC) in partnership with basic science departments (Biochemistry, Biophysics, Pharmacology & Toxicology, Cell Biology, Neuroscience & Anatomy, Microbiology & Immunology) has made a strategic decision to expand on its strengths in Structural and Chemical Biology (SCB) and now invites applications for tenure-track positions at all levels.

This cluster recruitment seeks individuals to establish internationally leading research programs that apply the tools of structural biology to fundamental questions in cancer biology or cancer therapeutics. The ideal candidate will focus on cryo-EM (Single-particle Analysis (SPA) or in-situ cryo-ET) and SPA data science. 91大神is equipped with a state-of-the-art 200-keV cryo-EM with direct electron detector and energy filter capable of final data collection for sub-4脜 structure determination. 91大神Cryo-EM researchers have expanded instrumentation opportunities through participation in a statewide Cryo-EM consortium that includes the University of Wisconsin-Madison鈥檚 Cryo-EM Research Center, which is within 60 miles from 91大神and currently houses five new cryo-EMs, including two Titan Krios.

Qualifications. Applicants must have a doctoral degree in structural biology, biochemistry, biophysics or related discipline, at least two years of postdoctoral training, a strong publication record investigating structural and functional properties of biomolecules of cancer therapeutic relevance, and potential to obtain cancer-related extramural funding. 91大神is intent on attracting, developing, and retaining a diverse workforce and faculty body that reflects the community we serve. We value diversity of backgrounds, experience, thought, and perspectives to advance excellence in science and medicine. 91大神is a welcoming campus community with a strong culture of collaboration, partnership, and engagement with our surrounding community.

To apply. Please submit the following components to www.mcw.edu/careers (requisition #31368):

1. Cover letter
2. Curriculum vitae
3. Summary of research accomplishments (4-page maximum) and future research plans (4-page maximum)
4. Names and contact information of four references

Who We Are
The Marinelli Lab at MCW's Biophysics Department explores how cells function at a molecular level, focusing on membrane transport, signaling, and morphological changes. This research relies on state-of-the-art and novel computer simulation methods, rooted in statistical mechanics and machine-learning. Methodological developments constitute an integral part of the lab research agenda and encompass advanced computational approaches to integrate molecular modeling and wet-lab experiments. A hallmark of the lab work, both in understanding mechanisms and developing methods, is its synergistic collaboration with wet-lab researchers. The lab uses this interdisciplinary approach to advance our understanding of proteins and cellular membranes across molecular and supramolecular scales, aiding the discovery of new therapies against diseases.

Purpose
The Marinelli Lab is offering a Postdoctoral Researcher position to develop advanced computational methods for studying biomolecular systems. The role involves designing innovative machine learning techniques to integrate molecular simulations with experimental data, such as DEER, HDX-MS, NMR, and EM, and may include advancing enhanced sampling and analysis techniques. The successful candidate will have the opportunity to apply these methods to investigate mechanisms of membrane proteins and their interactions with the lipid bilayer, particularly in the contexts of infectious diseases, drug resistance, and cancer.

The role includes contributing to the execution and design of research projects in this area, collaborate with experimental partners, analyze data, present findings at scientific meetings, and prepare manuscripts for peer-reviewed publication.

The lab is committed to providing a rich learning experience while supporting professional growth and transition to career independence.

The position offers a competitive compensation salary aligned with National Institutes of Health (NIH) standards, along with healthcare and other benefits.

Resources
Lab members have access to both dedicated and shared high-performance computing resources, including advanced GPU servers reserved for the lab, through the 91大神Research Computing Center.

Characteristics of a Postdoctoral Appointment

It is expected that postdocs at MCW, with the assistance of their supervisor, will:

• Transition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.
• Be supervised by at least one senior scholar who actively promotes the postdoc's professional development.
• Establish an individual development plan (IDP) that incorporates equally the postdoc's career and training goals and the mentor's research goals.
• Pursue basic, clinical, or translational projects so long as effort is focused primarily on research.
• Publish results of the postdoc's research and scholarship during their appointment.

The postdoctoral appointment is temporary by nature, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).

As postdocs are important members of the host institution's community, appropriate levels of compensation, health care, and other benefits commensurate with their essential status should be afforded, independent of the postdoc's source of funding.

Primary Functions

• Plan, design and execute complex research studies, procedures and protocols.
• Participate in discovery projects.
• Coordinate research study activities; lead and manage projects.
• Oversee organization, synthesis and analysis of data and findings.
• Prepare scientific reports, outcome findings and scientific manuscripts.
• Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
• Maintain supplies, may require negotiation with vendors, and track purchase orders.
• May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.

Knowledge – Skills – Abilities
Required knowledge: biology, chemistry, mathematics, statistics, documentation, records management, data utilization, complex problem solving, critical thinking, resource management, and writing skills

Skills and abilities: This will vary based on the hiring manager’s preferences and should include things that can be learned or trained for.

Purpose
A postdoctoral fellowship position is open in the Department of Biophysics at the 91大神 College of Wisconsin focusing on magnetic resonance imaging (MRI) technology development. This project will be dedicated to the deep learning-driven design of MRI pulse sequences, image reconstruction algorithms, and the quantitative estimation of tissue parameters. These efforts contribute to a larger initiative aimed at enhancing the accuracy and reproducibility of quantitative MRI. The Center for Imaging Research at 91大神houses two cutting-edge GE Premier 3T MRI systems, which will play a significant role in the research. We are seeking a candidate who is eager to work in a team-oriented laboratory environment that emphasizes innovation. The role includes mentoring graduate students in research methodologies, engaging in scientific publication, and preparation of grant proposals.

Primary Functions
Supervise and independently execute studies related to the project described above, including performing experiments, analyzing data, and disseminating results through presenting at conferences and writing manuscripts.

Knowledge 鈥� Skills 鈥� Abilities
Ideal candidates will have experience expertise in one or more of the following:

• MRI pulse sequence design (GE HealthCare EPIC Preferred)
• Programming in Python and C/C++
• Machine learning with PyTorch
• Excellent writing skills, as evidenced by first author publications

Purpose
Under general supervision, provide support for department research through projects, maintenance and communication of data, and execution of laboratory experiments. Support research on the structure and dynamics and in vivo function of bacterial proteins identified as drug targets for the development of novel antibiotics.

Primary Functions

• Carry out experimental designs for sponsored research projects and perform routine experiments.
• Record and compile accurate records and communicate summaries of experimental results.
• Assist with the evaluation, interpretation, and assessment of experimental data and quality control of assays.
• Participate in meetings with principal investigator and research staff and evaluate/interpret the validity of data as needed.
• Carry out assigned duties for ordering and maintaining supply of inventories.
• Operate, calibrate, and perform routine maintenance on specialized equipment used in research.
• Prepare media and buffers and perform routine laboratory maintenance.
• Express and purify recombinant proteins from E. coli using column chromatography.
• Label, concentrate, and prepare samples for EPR spectroscopy and other biophysical studies.
• Operate specialized EPR spectroscopy instrumentation as trained.
• Carry out in vivo growth assays.
• Perform other scientific and administrative duties as assigned.

Knowledge – Skills – Abilities
Ability to meticulously carry out experiments as trained. Ability to accurately determine basic math and chemistry calculations, maintain records, and carry out experiments in a timely and organized manner. Ability to work independently with proper training. Attention to detail. Honesty. Integrity. Experience in growing bacterial cultures, making buffers and media, carrying out molecular biology and microbiology assays and purifying protein from bacteria will be highly beneficial.