91΄σΙρ

91΄σΙρ College of Wisconsin
91΄σΙρ College of Wisconsin 91΄σΙρ College of Wisconsin
Research Lab Bench
Physiology
Chun Liu, PhD

Chun Liu, PhD

Assistant Professor

Locations

  • MEB M4565

Contact Information

Education

Postdoctoral Fellowship, Stanford Cardiovascular Institute, Stanford University
PhD, Peking University
BS, China Agricultural University

Biography

Dr. Chun Liu is an Assistant Professor of Physiology and Medicine at the 91΄σΙρ College of Wisconsin, and a member of Cardiovascular Center and Cancer Center. He obtained his PhD in stem cell biology from Peking University, mentored by Dr. Hongkui Deng. During his doctoral studies, Dr. Liu developed a chemical cocktail to reprogram somatic cells into iPSCs, a foundational work in the field of chemical-based iPSC reprogramming. Subsequently, he completed a postdoctoral fellowship in cardiovascular disease research at Stanford Cardiovascular Institute, under the guidance of Dr. Joseph Wu, MD, PhD. His work there included probing the pathogenic mechanisms underlying Lamin A/C mutation-induced dilated cardiomyopathy with patient-specific iPSC-derived cardiomyocytes (CMs) and endothelial cells (ECs), and researching new therapeutic drugs. Dr. Liu leveraged his expertise in iPSC, multiomics, and high-throughput CRISPRi/a screens to uncover novel genetic regulators in areas of genetic heart disease and drug-induced cardiomyopathy, including cardio-oncology. These innovative approaches offer a comprehensive view of the human genome's role in genetic and drug toxicity-induced cardiovascular disease, opening a new era of understanding heart diseases and targeted treatment. Dr. Liu's research has gained significant supported through various awards and grants such as the American Heart Association (AHA) Postdoctoral Award, Stanford Cardiovascular Institute Seed Grant, AHA Career Development Award, Startup Fund from MCW, and, recently, AHA’s Second Century Early Faculty Independence Award.

Honors and Awards

2023-2026 - American Heart Association Second Century Early Faculty Independence Award
2019-2022 - American Heart Association Career Development Award
2021 - American Heart Association Scientific Session Travel Award
2021 - Stanford Cardiovascular Institute Travel Award
2016-2018 - American Heart Association Postdoctoral Fellowship
2013 - Peking University Innovation Prize, Beijing, China

Research Areas of Interest

  • Cancer Survivors
  • Cardiovascular Diseases
  • Cell Differentiation
  • Cellular Reprogramming Techniques
  • CRISPR-Cas Systems
  • Epigenomics
  • Genomics
  • Induced Pluripotent Stem Cells
  • Pharmacogenetics
  • Systems Biology

Research Experience

  • Cell Differentiation
  • Cellular Reprogramming
  • CRISPR-Cas Systems
  • Endothelial Cells
  • Gene Expression Profiling
  • Induced Pluripotent Stem Cells
  • Myocytes, Cardiac

Methodologies and Techniques

  • Cardiovascular Diseases
  • Chromatin Immunoprecipitation
  • CRISPR-Cas Systems
  • High-Throughput Nucleotide Sequencing
  • Induced Pluripotent Stem Cells
  • Sequence Analysis, DNA
  • Sequence Analysis, RNA

Research Interests

WE ARE HIRING! Dr. Liu is passionate about mentoring and cultivating the next generation of scientific minds. Opportunities abound in our lab for talented students at both the graduate and undergraduate levels, as well as postdoctoral researchers. Engage with highly innovative projects that are currently underway, focusing on the fascinating fields of stem cell research and genomics. If these areas spark your interest, please don't hesitate to reach out to Dr. Liu directly. Your future in cutting-edge scientific exploration could begin with us!

  • Methodologies and Techniques
  • Induced pluripotent stem cell (iPSC)/reprogramming
  • Human cardiovascular differentiation (cardiomyocyte, endothelial cell, smooth muscle cell, and pericyte)
  • Genome editing (CRISPR and base editing)
  • CRISPRi/a screen
  • Perturb-seq
  • Transcriptomic/Epigenomic/Proteomic analysis
  • Vascular function
  • Cardiomyocyte function Mentoring and Training

Publications

  • (Belbachir N, Wu Y, Shen M, Zhang SL, Zhang JZ, Liu C, Knollmann BC, Lyon GJ, Ma N, Wu JC.) Circulation. 2023 Nov 14;148(20):1598-1601 PMID: 37956223 PMCID: PMC10697282 11/13/2023

  • (Colville A, Liu JY, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee JW, Lai C, Wu JC, Bassik MC, Rando TA.) Cell Metab. 2023 Oct 03;35(10):1814-1829.e6 PMID: 37699398 PMCID: PMC10597643 09/13/2023

  • (Shen M, Zhao SR, Khokhar Y, Li L, Zhou Y, Liu C, Wu JC.) STAR Protoc. 2023 Apr 27;4(2):102256 PMID: 37119139 PMCID: PMC10173856 04/29/2023

  • (Shen M, Liu C, Zhao SR, Manhas A, Sundaram L, Ameen M, Wu JC.) Circulation. 2023 Feb 07;147(6):515-518 PMID: 36745700 PMCID: PMC9909621 02/07/2023

  • (Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT.) Circ Res. 2023 Jan 20;132(2):187-204 PMID: 36583388 PMCID: PMC9852089 12/31/2022

  • (Chun Liu, Mengcheng Shen, Wilson L. W. Tan, Ian Y. Chen, Yu Liu, Xuan Yu, Huaxiao Yang, Angela Zhang, Yanxia Liu, Ming-Tao Zhao, Mohamed Ameen, Mao Zhang, Eric R. Gross, Lei S. Qi, Nazish Sayed & Joseph C. Wu.) Nature Cardiovascular Research. (2023). https://doi.org/10.1038/s44161-023-00267-1 05/08/2023

  • (Yang Y, Liu A, Tsai CT, Liu C, Wu JC, Cui B.) Biosens Bioelectron. 2022 Nov 15;216:114617 PMID: 36027802 PMCID: PMC9930661 08/27/2022

  • (Nishiga M, Liu C, Qi LS, Wu JC.) Nat Rev Cardiol. 2022 Aug;19(8):505-521 PMID: 35145236 PMCID: PMC10283450 02/12/2022

  • (Wang J, Soto F, Ma P, Ahmed R, Yang H, Chen S, Wang J, Liu C, Akin D, Fu K, Cao X, Chen P, Hsu EC, Soh HT, Stoyanova T, Wu JC, Demirci U.) ACS Nano. 2022 Jul 26;16(7):10219-10230 PMID: 35671037 06/08/2022

  • (Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC.) Cell. 2022 May 12;185(10):1676-1693.e23 PMID: 35489334 PMCID: PMC9400797 05/01/2022

  • (Shen M, Liu C, Wu JC.) Methods Mol Biol. 2022;2429:233-246 PMID: 35507165 PMCID: PMC9667909 05/05/2022

  • (Zhang M, Qian L, Liu C, Huang GN, Tao G.) Front Cell Dev Biol. 2021;9:730622 PMID: 34409043 PMCID: PMC8365607 08/20/2021

Publications of from the