91大神

91大神 College of Wisconsin
91大神 College of Wisconsin 91大神 College of Wisconsin
Research Group Lab Hall
Pharmacology and Toxicology
Christopher-Olsen-PhD

Christopher M. Olsen, PhD

Associate Professor

Locations

  • Pharmacology and Toxicology

Contact Information

General Interests

Neuroscience, Addictive Behavior and Novelty Seeking

Education

PhD, Toxicology and Neuroscience, University of Texas, 2004
MS, Texas Tech University, 1998
BA, Baylor University, 1994

Research Experience

  • Brain Concussion
  • Brain Injuries
  • Brain Injury, Chronic
  • Cocaine-Related Disorders
  • Exploratory Behavior
  • Motivation
  • Opioid-Related Disorders
  • Substance-Related Disorders

91大神Program / Core Facilities

  • Neuroscience Research Center

Research Interests

Olsen Lab

Addiction is a chronically relapsing disorder that is strongly modulated by positive and negative environmental factors. Our lab (olsenlab.org) focuses on how these environmental factors can influence drug intake and drug seeking using rat and mouse models of addiction.

We have two major projects to investigate environmental factors and addiction:

Environmental modulation of drug seeking ensembles. Transgenic approaches are used to identify and manipulate cells that are engaged during drug seeking following intravenous drug self-administration. We are studying the effects of positive and negative environmental factors on drug seeking and the activity of cells within drug seeking ensembles.

The impact of mild traumatic brain injury (mTBI) on addiction and mesocorticolimbic function. This work is done in collaboration with Drs. Brain Stemper and Matthew Budde in the Department of Biomedical Engineering and Neurosurgery, respectively. We are examining the effects of mTBI on drug self-administration, drug seeking, and mesocorticolimbic function using diffusion tensor imaging (DTI) and functional connectivity.

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Olsen Lab Image 1

Identification of neuronal ensembles involved in persistent drug seeking. TetTag (green) cells are those engaged during an initial drug seeking session, Fos+ (red) cells are those engaged during a second drug seeking session 2 weeks later.

Olsen Lab Image 2

Quantification of monocytes/microglia. Iba1+ (green) cells are surface rendered for complex analysis to examine long-lasting effect of mild traumatic brain injury on immune cells within the brain. Gray=nuclei (DAPI).

Publications

  • (Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM.) Behav Brain Res. 2023 Feb 13;438:114181 PMID: 36330906 PMCID: PMC9993345 SCOPUS ID: 2-s2.0-85140915448 11/05/2022

  • (Raff H, Glaeser BL, Szabo A, Olsen CM, Everson CA.) Stress. 2023 Jan;26(1):2185864 PMID: 36856367 PMCID: PMC10339708 SCOPUS ID: 2-s2.0-85150079770 03/02/2023

  • (Jessen K, Slaker Bennett ML, Liu S, Olsen CM.) J Neurosci Res. 2022 Apr;100(4):1008-1029 PMID: 35137974 PMCID: PMC8940716 02/10/2022

  • (Muelbl MJ, Glaeser BL, Shah AS, Chiariello RA, Nawarawong NN, Stemper BD, Budde MD, Olsen CM.) Addict Biol. 2022 Mar;27(2):e13134 PMID: 35229952 PMCID: PMC8896287 SCOPUS ID: 2-s2.0-85125380733 03/02/2022

  • (Olsen CM, Corrigan JD.) Biol Psychiatry. 2022 Mar 01;91(5):421-437 PMID: 34561027 PMCID: PMC8776913 09/26/2021

  • (Olsen CM, Herrold AA, Conti AC, Vonder Haar C.) Front Behav Neurosci. 2022;16:1010395 PMID: 36160681 PMCID: PMC9490366 09/27/2022

  • (Stemper BD, Shah A, Chiariello R, McCarthy C, Jessen K, Sarka B, Seifert J, Budde MD, Wang K, Olsen CM, McCrea M.) Front Behav Neurosci. 2022;16:805124 PMID: 35368301 PMCID: PMC8965565 SCOPUS ID: 2-s2.0-85127445249 04/05/2022

  • (Raber J, Holden S, Sudhakar R, Hall R, Glaeser B, Lenarczyk M, Rockwell K, Nawarawong N, Sterrett J, Perez R, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen CM, Willey JS, Bobe G, Baker J.) Front Physiol. 2021;12:746509 PMID: 34646164 PMCID: PMC8503608 SCOPUS ID: 2-s2.0-85116920048 10/15/2021

  • (Nawarawong NN, Olsen CM.) Behav Brain Res. 2020 Feb 03;379:112275 PMID: 31614186 PMCID: PMC7937550 10/16/2019

  • (Nawarawong NN, Slaker M, Muelbl M, Shah AS, Chiariello R, Nelson LD, Budde MD, Stemper BD, Olsen CM.) Eur J Neurosci. 2019 Aug;50(3):2101-2112 PMID: 30456793 PMCID: PMC6814147 SCOPUS ID: 2-s2.0-85058419226 11/21/2018

  • (Muelbl MJ, Slaker ML, Shah AS, Nawarawong NN, Gerndt CH, Budde MD, Stemper BD, Olsen CM.) Sci Rep. 2018 Jul 02;8(1):9941 PMID: 29967344 PMCID: PMC6028456 SCOPUS ID: 2-s2.0-85049369592 07/04/2018

  • (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.) iScience. 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018

Publications of from the