91΄σΙρ

91΄σΙρ College of Wisconsin
91΄σΙρ College of Wisconsin 91΄σΙρ College of Wisconsin
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Hematology and Oncology
Xiao Chen Headshot

Xiao Chen, MD, PhD

Associate Professor

Locations

  • 91΄σΙρ College of Wisconsin
    Department of Medicine
    Division of Hematology and Oncology

Biography

Dr. Xiao Chen is Associate Professor of Medicine at the 91΄σΙρ College of Wisconsin, Division of Hematology and Oncology. He obtained his medical degree from Fujian 91΄σΙρ University in China and PhD degree in immunology from the Technical University of Dresden in Germany.

Research Interests

Dr. Chen has a longstanding commitment to research in hematology and immunology with a particular interest and expertise in graft-versus-host disease (GVHD). Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for many serious diseases including hematologic malignancies. Each year, thousands of patients diagnosed with leukemia, lymphoma, and multiple myeloma will depend on a stem cell transplant for a second chance at life. Unfortunately, GVHD remains a serious and frequently fatal complication following allogeneic HSCT. The long-term research goal of the Chen lab is to develop clinically relevant strategies to prevent or mitigate GVHD, making allogeneic HSCT a safer treatment for cancer patients. A major theme of Dr. Chen’s research program is to define the potential role of dietary and nutritional factors in the pathogenesis and management of GVHD. Specifically, the lab has been investigating how vitamins A and D as well as prebiotics modulate GVHD risk. Since diet is one of the most important factors that shape gut microbiota, recent research in the lab has focused on how nutritional factors influence GVHD by modulating gut microbiota. The lab is using genetic, nutritional, and immunological approaches in combination with next-generation sequencing techniques to study the complex interplay between nutrients, gut microbiota, and mucosal immune responses during GVHD. The potential use of nutritional interventions to correct gut dysbiosis and mitigate GVHD is being explored. Dr. Chen also has a strong interest in tumor immunology and cellular immunotherapy.

Publications

  • (Limpert R, Pan P, Wang LS, Chen X.) Front Immunol. 2023;14:1192084 PMID: 37359550 PMCID: PMC10285162 SCOPUS ID: 2-s2.0-85162622656 06/26/2023

  • (Tian L, Wu Y, Choi HJ, Sui X, Li X, Sofi MH, Kassir MF, Chen X, Mehrotra S, Ogretmen B, Yu XZ.) Cell Mol Immunol. 2022 Nov;19(11):1235-1250 PMID: 36071219 PMCID: PMC9622814 SCOPUS ID: 2-s2.0-85137418710 09/08/2022

  • (Dong A, Pan X, Lin CW, Huang YW, Krause H, Pan P, Baim A, Thomas MJ, Chen X, Yu J, Michaelis L, Liu P, Wang LS, Atallah E.) J Cancer Prev. 2022 Jun 30;27(2):129-138 PMID: 35864858 PMCID: PMC9271408 07/23/2022

  • (Dong A, Lin CW, Echeveste CE, Huang YW, Oshima K, Yearsley M, Chen X, Yu J, Wang LS.) J Cancer Prev. 2022 Mar 30;27(1):50-57 PMID: 35419306 PMCID: PMC8984655 04/15/2022

  • (Dong A, Huang YW, Yearsley M, Oshima K, Chen X, Yu J, Wang LS.) Food Front. 2021 Sep;2(3):324-328 PMID: 35360278 PMCID: PMC8963127 04/02/2022

  • (Pan P, Atkinson SN, Taylor B, Zhu H, Zhou D, Flejsierowicz P, Wang LS, Morse M, Liu C, Gunsolus IL, Chen X.) Front Immunol. 2021;12:749002 PMID: 34759928 PMCID: PMC8573259 SCOPUS ID: 2-s2.0-85118722452 11/12/2021

  • (Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D.) J Immunol. 2020 Dec 15;205(12):3480-3490 PMID: 33158956 PMCID: PMC7955895 SCOPUS ID: 2-s2.0-85097490484 11/08/2020

  • (Pan P, Chen X.) Cells. 2020 Aug 19;9(9) PMID: 32824945 PMCID: PMC7563802 SCOPUS ID: 2-s2.0-85089806628 08/23/2020

  • (Zheng J, Taylor B, Dodge J, Stephans A, Zheng SG, Chen Q, Chen X.) Am J Transplant. 2020 Jan;20(1):64-74 PMID: 31207088 PMCID: PMC6918002 SCOPUS ID: 2-s2.0-85069712148 06/18/2019

  • (Cai W, Wang J, Hu M, Chen X, Lu Z, Bellanti JA, Zheng SG.) J Neuroinflammation. 2019 Aug 31;16(1):175 PMID: 31472680 PMCID: PMC6717357 SCOPUS ID: 2-s2.0-85071686674 09/02/2019

  • (Chen X, Mayne CG.) Front Immunol. 2018;9:2853 PMID: 30574143 PMCID: PMC6291446 SCOPUS ID: 2-s2.0-85058870758 12/24/2018

  • (Zheng J, Taylor B, Chen X.) J Immunol Res Ther. 2018;3(1):124-128 PMID: 30101210 PMCID: PMC6086377 08/14/2018

Publications of from the