91大神

91大神 College of Wisconsin
91大神 College of Wisconsin 91大神 College of Wisconsin
Research Collaborate Lab Bench
Biochemistry
Brian Volkman, PhD

Brian F. Volkman, PhD

Director, Program in Chemical Biology; Professor, Biochemistry

Locations

  • Biochemistry
    TBRC C3815

Contact Information

Education

PhD, University of California at Berkeley, 1994
BS, Butler University, 1989

Biography

Dr. Volkman obtained his Bachelor of Science degree in Chemistry and Physics from Butler University in 1989 and his Doctorate degree from The University of California at Berkeley. The latter was awarded in 1994 for structural studies on proteins involved in bacterial gene regulation using NMR spectroscopy. Dr. Volkman's postdoctoral training was in the Department of Biochemistry at the University of Wisconsin-Madison. In 2000, Dr. Volkman started at the 91大神 College of Wisconsin where he is Professor in the Biochemistry Department. Dr. Volkman's work focuses on the structural biology of immunological signaling molecules and the use of NMR spectroscopy in structural proteomics.

Research Experience

  • Amino Acid Sequence
  • Binding Sites
  • Chemokine CCL21
  • Chemokine CXCL12
  • Chemokines
  • Chemokines, C
  • Chemokines, CXC
  • Chemotaxis
  • Computational Biology
  • Crystallography, X-Ray
  • Dimerization
  • Drug Design

Research Interests

Our goal is to invent new ways to treat cancer and other ailments by examining the three-dimensional architecture of proteins involved in disease and synthesizing new drug candidate molecules. This research links the expertise of chemists, structural biologists, and clinician-scientists who collaborate in the design and testing of potential therapies. Graduate students in my group have invented and patented new compounds that show promise as treatments for cancer and psoriasis. Your donation helps us accelerate the drug development process by paying for preclinical studies that most research grants simply won’t support - bridging the gap between our basic science discoveries and clinical trials. 

We use NMR spectroscopy and many other techniques to (1) understand the transmission of biological signals in terms of molecular structure, recognition and dynamics and (2) exploit this knowledge for the design and discovery of new molecules with practical utility as research tools, bioactive nanomaterials, or new drugs.

Dynamics and folding. Protein function is exquisitely dependent on compactly folded structures that combine energetic stability with intrinsic flexibility. Our work has revealed surprising and altered the established paradigm for protein folding to include the new category of . We are now trying to define the and evolutionary origins of metamorphic folding using the divergence of human lymphotactin from the rest of the chemokine family as a prototypical example. Other projects analyze novel modes of conformational switching that control and enzyme activity.

Molecular recognition. Biological signals are often controlled by promoting or disrupting the interaction between two proteins. Many chemokines have been directly implicated in human diseases. Compounds that might function as inhibitors of inflammation, , viral infection or autoimmune disease. We recently used NMR to solve the , and subsequently used the details of this interface to search for that bind the chemokine and block its activity. A to inhibitor screening is now being used to with the ultimate goal of drug discovery to treat and psoriasis.

Lab Photo

Volkman Lab

Back Row L. to R.: Chris Veldkamp, Francis Peterson, Rob Tyler, Anthony Getschman (hands), Austin Jiang,
Alex Chadwick, Davin Jensen, Dustin Whitney and Josh Weiner
Middle Row L. to R.: Chad Koplinski, Amanda Nevins
First Row L. to R.: Dr. Brian Volkman, Echo the dog, Jamie Wieting, Becky Holme

Publications

  • (Pontejo SM, Martinez S, Zhao A, Barnes K, de Anda J, Alimohamadi H, Lee EY, Dishman AF, Volkman BF, Wong GCL, Garboczi DN, Ballesteros A, Murphy PM.) bioRxiv. 2024 Jul 25 PMID: 39091850 PMCID: PMC11291121 08/02/2024

  • (Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF.) Nat Commun. 2024 May 30;15(1):4611 PMID: 38816420 PMCID: PMC11139983 SCOPUS ID: 2-s2.0-85194992751 05/31/2024

  • (Park SY, Qiu J, Wei S, Peterson FC, Beltrán J, Medina-Cucurella AV, Vaidya AS, Xing Z, Volkman BF, Nusinow DA, Whitehead TA, Wheeldon I, Cutler SR.) Nat Chem Biol. 2024 Jan;20(1):103-110 PMID: 37872402 PMCID: PMC10746540 SCOPUS ID: 2-s2.0-85174576715 10/24/2023

  • (Powers HR, Jenjak SE, Volkman BF, Sahoo D.) J Biol Chem. 2023 Oct;299(10):105187 PMID: 37625590 PMCID: PMC10509710 SCOPUS ID: 2-s2.0-85171377774 08/26/2023

  • (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) bioRxiv. 2023 Sep 07 PMID: 37786696 PMCID: PMC10541560 10/03/2023

  • (Praetorius F, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, Pillai A, Idris A, Juergens D, Dauparas J, Li X, Levine PM, Lamb M, Ballard RK, Gerben SR, Nguyen H, Kang A, Sankaran B, Bera AK, Volkman BF, Nivala J, Stoll S, Baker D.) Science. 2023 Aug 18;381(6659):754-760 PMID: 37590357 PMCID: PMC10697137 SCOPUS ID: 2-s2.0-85168284894 08/17/2023

  • (Dishman AF, Volkman BF.) Trends Biochem Sci. 2023 Aug;48(8):665-672 PMID: 37270322 PMCID: PMC10526677 SCOPUS ID: 2-s2.0-85160689793 06/04/2023

  • (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023

  • (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023

  • (Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC.) Methods Enzymol. 2023;690:285-310 PMID: 37858532 PMCID: PMC10657026 SCOPUS ID: 2-s2.0-85166280504 10/20/2023

  • (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT.) Comput Struct Biotechnol J. 2023;21:4790-4803 PMID: 37841325 PMCID: PMC10570560 10/16/2023

  • (Shi ZR, Mabuchi T, Riutta SJ, Wu X, Peterson FC, Volkman BF, Hwang ST.) Journal of Psoriasis and Psoriatic Arthritis. July 2023;8(3):107-117 SCOPUS ID: 2-s2.0-85150743226 07/01/2023

Publications of from the